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  • 產(chǎn)品名稱(chēng)：Anti-FLNA antibody (2348-2647) (STJ118804)

  • 產(chǎn)品型號(hào)：STJ118804
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-FLNA antibody (2348-2647) (STJ118804)
詳情介紹：
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FLNA (2348-2647) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FLNA
Gene ID: 2316
Uniprot ID: FLNA_HUMAN
Immunogen Region: 2348-2647
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 2348-2647 of human Filamin A (NP_001104026.1).
Immunogen Sequence: NQPASFAVSLNGAKGAIDAK VHSPSGALEECYVTEIDQDK YAVRFIPRENGVYLIDVKFN GTHIPGSPFKIRVGEPGHGG DPGLVSAYGAGLEGGVTGNP AEFVVNTSNAGAGALSVTID GPSKVKMDCQECPEGYRVTY TPMAPGSYLISIKYGGPYHI GGSPFKAKVTGPRLVSNHSL HETSSVFVDSLTKATCAPQH GAPGPGPADASKVVAKGLGL SKAYVGQKSSFTVDCSKAG
Tissue Specificity Ubiquitous.
Post Translational Modifications Phosphorylation at Ser-2152 is negatively regulated by the autoinhibited conformation of filamin repeats 19-21. Ligand binding induces a conformational switch triggering phosphorylation at Ser-2152 by PKA. Phosphorylation extent changes in response to cell activation. Polyubiquitination in the CH1 domain by a SCF-like complex containing ASB2 leads to proteasomal degradation. Prior dissociation from actin may be required to expose the target lysines. Ubiquitinated in endothelial cells by RNF213 downstream of the non-canonical Wnt signaling pathway, leading to its degradation by the proteasome.
Function Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance. During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons.
Protein Name Filamin-A
Fln-A
Actin-Binding Protein 280
Abp-280
Alpha-Filamin
Endothelial Actin-Binding Protein
Filamin-1
Non-Muscle Filamin
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-430116
Reactome: R-HSA-446353
Reactome: R-HSA-5627123
Reactome: R-HSA-8983711
Cellular Localisation Cytoplasm
Cell Cortex
Cytoskeleton
Perikaryon
Cell Projection
Growth Cone
Colocalizes With Cpmr1 In The Central Region Of Drg Neuron Growth Cone
Following Sema3a Stimulation Of Drg Neurons
Colocalizes With F-Actin
Alternative Antibody Names Anti-Filamin-A antibody
Anti-Fln-A antibody
Anti-Actin-Binding Protein 280 antibody
Anti-Abp-280 antibody
Anti-Alpha-Filamin antibody
Anti-Endothelial Actin-Binding Protein antibody
Anti-Filamin-1 antibody
Anti-Non-Muscle Filamin antibody
Anti-FLNA antibody
Anti-FLN antibody
Anti-FLN1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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